Figure 1.

Genome-wide eRNA identification. (A) Venn diagram shows the number of all the intergenic transcribed regions (outer circle, light blue), high confidence enhancer regions (middle circle, blue), and inducible enhancer regions (inner circle, dark blue). (B) Heat map summarizes GRO-seq data in eRNA-TSS flanking regions (from 1 kb upstream to 2 kb downstream). eRNAs from + (yellow) and − (purple) strands are shown separately. Predicted eRNA-expressing enhancer regions are centered at the TSS. (C) Heat map (upper panel) and metagene profiles (lower panel) are plotted for epigenetic signals including H3K4me1, H3K27ac, and EP300 ChIP-seq, DNase-seq, and MNase-seq data.