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. 2018 Oct 2;19(12):e46512. doi: 10.15252/embr.201846512

Figure 1. PRN1126 is selective for the chymotrypsin‐like activity of the immunoproteasome.

Figure 1

  • A
    Structure of PRN1126, a reversible covalent selective LMP7 inhibitor.
  • B, C
    Hydrolysis of fluorogenic substrates (Suc‐LLVY‐AMC) for the chymotrypsin‐like activity of human (B) or mouse (C) 20S constitutive proteasome (CP) or 20S immunoproteasome (IP) at various PRN1126 concentrations. Data are presented as the means ± s.d. from quadruplicate assays. The highest fluorescence value was set to 100%. The experiments were repeated twice with similar results.