Table 2.
Recovered dose (RD), emitted dose (ED), percent recovery, percent emission, percent impact loss, mass median aerodynamic diameter (MMAD), geometric standard deviation (GSD), fine particle dose (FPD), fine particle fraction (FPF), drug loss (DL), dispersibility (DS), and effective inhalation index (EI) of salbutamol sulfate obtained from each of the different formulations (spray-dried lactose monohydrate and spray-dried lactose-leucine where the concentrations of leucine were 0.1, 0.5, 1, 5, and 10%)
| Formulation | RD (μg) | ED (μg) | Recovery (%) | Emission (%) | Impact loss (%) | MMAD (μm) | GSD (μm) | FPD (μg) | FPF (%) | DL (%) | DS (%) | EI |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SD lactose | 434.09 ± 40.27 | 376.79 ± 19.65 | 90.25 ± 8.37 | 87.02 ± 3.79 | 52.49 ± 2.81 | 3.13 ± 0.15 | 2.18 ± 0.07 | 110.41 ± 4.77 | 25.51 ± 1.23 | 14.31 ± 4.12 | 29.31 ± 0.36 | 10.87 ± 0.22 |
| 0.1% L-leucine | 455.47 ± 53.13 | 398.95 ± 29.95 | 94.69 ± 11.05 | 87.92 ± 4.89 | 43.46 ± 10.14 | 3.19 ± 0.09 | 2.09 ± 0.03 | 158.53 ± 39.73 | 34.99 ± 8.89 | 13.72 ± 5.34 | 39.62 ± 8.79 | 10.93 ± 0.39 |
| 0.5% L-leucine | 542.26 ± 297.51 | 520.92 ± 281.30 | 112.74 ± 61.85 | 96.41 ± 1.23 | 34.61 ± 12.38 | 3.26 ± 0.05 | 2.09 ± 0.01 | 262.28 ± 156.60 | 47.11 ± 9.94 | 4.14 ± 1.52 | 48.94 ± 10.78 | 11.98 ± 0.37 |
| 1% L-leucine | 363.63 ± 49.05 | 342.77 ± 51.17 | 75.60 ± 10.20 | 94.15 ± 1.54 | 37.60 ± 10.86 | 3.16 ± 0.13 | 2.10 ± 0.03 | 159.45 ± 14.31 | 44.33 ± 6.53 | 6.55 ± 1.53 | 47.12 ± 7.23 | 11.77 ± 0.26 |
| 5% L-leucine | 297.32 ± 175.08 | 272.87 ± 179.66 | 61.81 ± 36.40 | 88.91 ± 7.43 | 35.95 ± 4.00 | 3.00 ± 0.18 | 2.13 ± 0.08 | 134.81 ± 91.41 | 43.08 ± 7.38 | 12.00 ± 8.18 | 48.26 ± 5.35 | 11.48 ± 0.63 |
| 10% L-leucine | 366.52 ± 166.33 | 338.81 ± 149.50 | 76.20 ± 34.58 | 92.82 ± 2.34 | 38.74 ± 22.45 | 2.99 ± 0.23 | 2.12 ± 0.08 | 174.83 ± 121.38 | 44.50 ± 17.40 | 7.82 ± 2.26 | 48.27 ± 19.67 | 11.71 ± 0.66 |