Table 2.
Lipid classes associated with change in C-peptide adjusted for age, sex and HbA1c
| Outcome | Change in C-peptide, 1 to 3 month | Change in C-peptide, 1 to 6 month | Change in C-peptide, 1 to 12 month | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Lipid class | Change in outcome (pmol/L)a (95% CI) | p-value | p-value (Benjamini–Hochberg) | Change in outcome (pmol/L)a (95% CI) | p-value | p-value (Benjamini–Hochberg) | Change in outcome (pmol/L)a (95% CI) | p-value | p-value (Benjamini–Hochberg) |
| Dihydroceramide | 15.9 (− 36, 68) | 5.5E−01 | 8.0E−01 | 6.4 (−56, 69) | 8.4E−01 | 9.1E−01 | − 50.0 (− 135, 35) | 2.5E−01 | 4.2E−01 |
| Ceramide | 0.6 (− 62, 64) | 9.9E−01 | 1.0E+00 | − 75.8 (− 157, 5) | 7.0E−02 | 2.5E−01 | − 112.4 (− 206, − 19) | 2.1E−02 | 1.0E−01 |
| Monohexosylceramide | − 62.0 (− 112, − 12) | 1.6E−02 | 3.9E−01 | − 44.4 (− 108, 19) | 1.8E−01 | 5.2E−01 | − 64.2 (− 143, 15) | 1.1E−01 | 2.6E−01 |
| Dihexosylceramide | − 21.6 (− 77, 34) | 4.5E−01 | 7.7E−01 | − 26.4 (− 98, 46) | 4.8E−01 | 7.9E−01 | − 74.7 (− 159, 10) | 8.5E−02 | 2.3E−01 |
| Trihexosylceramide | − 5.3 (− 66, 55) | 8.6E−01 | 9.9E−01 | 14.0 (− 59, 87) | 7.1E−01 | 8.0E−01 | − 62.1 (− 153, 29) | 1.8E−01 | 3.5E−01 |
| GM3 ganglioside | − 30.0 (− 91, 31) | 3.4E−01 | 7.7E−01 | − 36.6 (− 113, 39) | 3.5E−01 | 7.2E−01 | − 100.1 (− 192, − 9) | 3.4E−02 | 1.2E−01 |
| Spinghomyelin | − 4.2 (− 54, 46) | 8.7E−01 | 9.9E−01 | 20.2 (− 50, 90) | 5.7E−01 | 8.0E−01 | − 33.7 (− 116, 49) | 4.2E−01 | 6.1E−01 |
| Alkylphosphatidylcholine | 13.4 (− 52, 79) | 6.9E−01 | 9.1E−01 | 40.1 (− 37, 117) | 3.1E−01 | 7.0E−01 | 29.0 (− 74, 132) | 5.8E−01 | 6.9E−01 |
| Alkenylphosphatidylcholine | 31.5 (− 25, 88) | 2.8E−01 | 7.7E−01 | 29.7 (− 40, 99) | 4.0E−01 | 7.2E−01 | 3.0 (− 85, 90) | 9.5E−01 | 9.6E−01 |
| Lysophosphatidylcholine | − 24.8 (− 79, 29) | 3.7E−01 | 7.7E−01 | 20.2 (− 46, 87) | 5.5E−01 | 8.0E−01 | − 1.9 (− 82, 78) | 9.6E−01 | 9.6E−01 |
| Lysoalkylphosphatidylcholine | − 36.5 (− 95, 22) | 2.2E−01 | 7.7E−01 | − 34.4 (− 113, 45) | 4.0E−01 | 7.2E−01 | − 75.0 (− 171, 21) | 1.3E−01 | 2.7E−01 |
| Phosphatidylethanolamine | − 0.5 (− 54, 53) | 9.9E−01 | 1.0E+00 | − 44.5 (− 117, 28) | 2.3E−01 | 5.8E−01 | − 24.7 (− 108, 59) | 5.6E−01 | 6.9E−01 |
| Alkylphosphatidylethanolamine | 21.6 (− 35, 79) | 4.6E−01 | 7.7E−01 | 15.1 (− 59, 89) | 6.9E−01 | 8.0E−01 | 102.4 (15, 190) | 2.4E−02 | 1.0E−-01 |
| Alkenylphosphatidylethanolamine | 25.1 (− 29, 79) | 3.6E−01 | 7.7E−01 | 0.9 (− 73, 75) | 9.8E−01 | 9.9E−01 | 33.5 (− 51, 118) | 4.4E−01 | 6.1E−01 |
| Phosphatidylglycerol | − 41.3 (− 99, 17) | 1.7E−01 | 7.7E−01 | − 93.7 (− 166, − 21) | 1.3E−02 | 8.0E−02 | − 74.1 (− 160, 11) | 9.2E−02 | 2.3E−01 |
| Lysophosphatidylethanolamine | − 10.0 (− 67, 47) | 7.3E−01 | 9.1E−01 | − 0.5 (− 72, 71) | 9.9E−01 | 9.9E−01 | 7.0 (− 74, 88) | 8.7E−01 | 9.6E−01 |
| Phosphatidylinositol | − 18.2 (− 72, 35) | 5.1E−01 | 7.9E−01 | − 22.7 (− 95, 50) | 5.4E−01 | 8.0E−01 | 5.4 (− 76, 87) | 9.0E−01 | 9.6E−01 |
| Lysophosphatidylinositol | − 22.4 (− 80, 35) | 4.5E−01 | 7.7E−01 | 49.4 (− 23, 122) | 1.9E−01 | 5.2E−01 | 49.9 (− 38, 138) | 2.7E−01 | 4.2E−01 |
| Phosphatidylserine | 9.4 (− 43, 62) | 7.3E−01 | 9.1E−01 | − 13.6 (− 81, 53) | 6.9E−01 | 8.0E−01 | − 52.1 (− 133, 29) | 2.1E−01 | 3.7E−01 |
| Cholesterol | 0.1 (− 58, 58) | 1.0E+00 | 1.0E+00 | 14.0 (− 57, 85) | 7.0E−01 | 8.0E−01 | − 23.3 (− 103, 56) | 5.7E−01 | 6.9E−01 |
| Cholesteryl ester | − 69.4 (− 136, − 3) | 4.3E−02 | 5.3E−01 | − 167.4 (− 252, − 83) | 1.8E−04 | 4.6E−03 | − 156.7 (− 257, − 56) | 2.9E−03 | 7.1E−02 |
| Diacylglycerol | − 49.6 (− 118, 18) | 1.6E−01 | 7.7E−01 | − 142.5 (− 230, − 55) | 1.9E−03 | 1.7E−02 | − 129.0 (− 228, − 30) | 1.2E−02 | 1.0E−01 |
| Triacylglycerol | − 46.6 (− 115, 22) | 1.9E−01 | 7.7E−01 | − 144.1 (− 233, − 55) | 2.1E−03 | 1.7E−02 | − 123.0 (− 220, − 26) | 1.4E−02 | 1.0E−01 |
| Oxidized cholesteryl ester | −32.8 (− 90, 24) | 2.6E−01 | 7.7E−01 | − 70.6 (− 145, 4) | 6.6E−02 | 2.5E−01 | − 84.4 (− 172, 3) | 6.1E−02 | 1.9E−01 |
| Oxidized phosphatidylcholine | 40.3 (− 19, 100) | 1.9E−01 | 7.7E−01 | 91.2 (17, 165) | 1.8E−02 | 8.9E−02 | 105.9 (17, 194) | 2.1E−02 | 1.0E−01 |
Bold values indicate statistical significance at p < 0.05
aAssociated with an IQR Increase in Predictor (1 month lipid) concentration