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. 2018 Aug 24;32(12):1173–1181. doi: 10.1007/s40263-018-0553-1
Natalizumab significantly improved NeuroTrax global cognitive score over 2 years of treatment, regardless of whether patients were treatment-naive or were previously treated with other disease-modifying therapies.
Numerical improvements were observed for all seven individual cognitive domains from baseline to 2 years.
These results indicate that some aspects of cognitive impairment can be reduced in patients with multiple sclerosis treated with natalizumab.