Table 3.
Association between body composition at 18 and 22 years and wheezing and atopy
| “Wheezing in the last year”a
|
“Only wheezing in the last year” (without atopy)b
|
“Wheezing + atopy in the last year”b
|
“Only atopy in the last year”b
|
|||||
|---|---|---|---|---|---|---|---|---|
| Crude
|
Adjusted
|
Crude
|
Adjusted
|
Crude
|
Adjusted
|
Crude
|
Adjusted
|
|
| 18 years/22 years | OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) |
|
| ||||||||
| BMI obese (≥30 kg/m2) | P=0.006 | P=0.013 | P=0.028 | P=0.043 | P=0.025 | P=0.015 | P=0.188 | P=0.942 |
| None | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| Only at 18 years | 1.26 (0.60, 2.67) | 1.28 (0.53, 3.11) | 0.90 (0.21, 3.79) | 0.71 (0.09, 5.42) | 1.63 (0.68, 3.92) | 1.83 (0.68, 4.99) | 1.20 (0.72, 2.03) | 1.29 (0.69, 2.42) |
| Only at 22 years | 1.20 (0.84, 1.73) | 1.19 (0.75, 1.88) | 0.96 (0.52, 1.79) | 0.73 (0.30, 1.75) | 1.26 (0.81, 1.96) | 1.63 (0.96, 2.76) | 0.87 (0.68, 1.12) | 1.19 (0.87, 1.63) |
| Both | 1.92 (1.35, 2.73) | 2.00 (1.32, 3.03) | 2.14 (1.27, 3.60) | 2.42 (1.31, 4.45) | 1.63 (1.03, 2.59) | 1.67 (0.96, 2.88) | 0.85 (0.63, 1.15) | 0.86 (0.60, 1.25) |
| Total fat mass – BOD POD % in the third tertile | P=0.226 | P=0.108 | P=0.567 | P=0.095 | P=0.128 | P=0.092 | P=0.845 | P=0.377 |
| None | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| Only at 18 years | 0.96 (0.63, 1.46) | 0.85 (0.50, 1.47) | 0.80 (0.39, 1.63) | 0.90 (0.37, 2.20) | 1.15 (0.69, 1.93) | 0.89 (0.46, 1.74) | 1.16 (0.89, 1.51) | 1.11 (0.80, 1.53) |
| Only at 22 years | 0.89 (0.57, 1.38) | 0.97 (0.57, 1.65) | 0.63 (0.29, 1.39) | 0.45 (0.14, 1.49) | 1.11 (0.66, 1.87) | 1.33 (0.74, 2.41) | 1.07 (0.81, 1.40) | 1.08 (0.77, 1.50) |
| Both | 1.28 (0.98, 1.67) | 1.42 (1.04, 1.95) | 1.21 (0.80, 1.83) | 1.69 (1.03, 2.78) | 1.31 (0.93, 1.83) | 1.38 (0.93, 2.06) | 0.97 (0.80, 1.17) | 1.10 (0.88, 1.38) |
| Total fat mass – DXA % in the third tertile | P=0.238 | P=0.048 | P=0.396 | P=0.053 | P=0.080 | P=0.021 | P=0.666 | P=0.371 |
| None | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| Only at 18 years | 1.01 (0.64, 1.58) | 0.98 (0.56, 1.73) | 1.00 (0.49, 2.06) | 1.25 (0.53, 2.97) | 1.04 (0.59, 1.85) | 0.87 (0.42, 1.83) | 1.06 (0.79, 1.41) | 1.05 (0.75, 1.48) |
| Only at 22 years | 1.10 (0.71, 1.68) | 1.16 (0.68, 1.99) | 0.58 (0.24, 1.34) | 0.50 (0.15, 1.67) | 1.25 (0.76, 2.05) | 1.43 (0.79, 2.62) | 0.70 (0.52, 0.95) | 0.81 (0.57, 1.17) |
| Both | 1.34 (1.01, 1.77) | 1.58 (1.14, 2.20) | 1.33 (0.86, 2.08) | 1.88 (1.11, 3.19) | 1.36 (0.95, 1.94) | 1.60 (1.06, 2.42) | 1.02 (0.84, 1.24) | 1.16 (0.92, 1.47) |
| Trunk fat mass – DXA % in the third tertile | P=0.324 | P=0.064 | P=0.595 | P=0.086 | P=0.078 | P=0.014 | P=0.876 | P=0.108 |
| None | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| Only at 18 years | 0.95 (0.60, 1.48) | 0.93 (0.53, 1.63) | 0.75 (0.35, 1.59) | 0.90 (0.37, 2.22) | 0.99 (0.57, 1.73) | 0.84 (0.42, 1.70) | 0.85 (0.64, 1.14) | 0.78 (0.55, 1.11) |
| Only at 22 years | 1.03 (0.67, 1.58) | 1.13 (0.67, 1.91) | 0.35 (0.13, 0.98) | 0.30 (0.07, 1.28) | 1.35 (0.83, 2.18) | 1.59 (0.90, 2.83) | 0.77 (0.58, 1.03) | 0.89 (0.63, 1.26) |
| Both | 1.29 (0.97, 1.71) | 1.54 (1.11, 2.16) | 1.30 (0.84, 2.01) | 1.84 (1.09, 3.10) | 1.34 (0.94, 1.93) | 1.65 (1.08, 2.51) | 1.07 (0.88, 1.30) | 1.26 (1.00, 1.59) |
| FMI in the third tertile | P=0.317 | P=0.113 | P=0.452 | P=0.133 | P=0.228 | P=0.126 | P=0.197 | P=0.816 |
| None | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| Only at 18 years | 0.96 (0.62, 1.48) | 0.78 (0.43, 1.40) | 1.05 (0.54, 2.02) | 1.11 (0.48, 2.57) | 0.83 (0.46, 1.48) | 0.58 (0.26, 1.29) | 0.87 (0.65, 1.15) | 0.88 (0.62, 1.25) |
| Only at 22 years | 1.02 (0.66, 1.56) | 1.01 (0.60, 1.69) | 0.82 (0.40, 1.67) | 0.66 (0.25, 1.73) | 1.01 (0.60, 1.71) | 1.14 (0.62, 2.10) | 0.78 (0.58, 1.03) | 0.82 (0.58, 1.17) |
| Both | 1.27 (0.98, 1.66) | 1.39 (1.02, 1.90) | 1.23 (0.81, 1.86) | 1.59 (0.97, 2.62) | 1.24 (0.89, 1.74) | 1.36 (0.92, 2.01) | 0.92 (0.76, 1.10) | 1.06 (0.85, 1.33) |
Notes: Atopy, self-reported rhinitis, and/or eczema symptoms in the last year previous to the 22 years interview. Adjusted by gender, skin color, asset index (quintiles), education (years), maternal smoking during pregnancy, parents smoking during infancy, hospitalization during infancy, parents history of asthma, wheezing or bronchitis, household crowding, smoking trajectory 18–22 years, and physical activity trajectory 18–22 years.
a
Logistic regression.
b
Multinomial logistic regression (reference category: no wheezing and/or atopy reported).
Abbreviations: BMI, body mass index; DXA, dualenergy X-ray absorptiometry; FMI, fat mass index.