Table S1.

Association between persistent wheezing and body composition at 18 and 22 years

	Persistent wheezing (18 and 22 years/with or without atopy)a
	Crude	Adjusted
18 years/22 years	OR (95% CI)	OR (95% CI)
BMI obese (≥30 kg/m2)	P=0.413	P=0.671
None	1.00	1.00
Only at 18 years	1.11 (0.34, 3.57)	1.50 (0.44, 5.05)
Only at 22 years	0.74 (0.37, 1.48)	0.77 (0.36, 1.64)
Both	1.50 (0.86, 2.61)	1.28 (0.66, 2.51)
Total fat mass – BOD POD % in the third tertile	P=0.923	P=0.937
None	1.00	1.00
Only at 18 years	1.11 (0.61, 2.02)	0.93 (0.43, 2.03)
Only at 22 years	0.88 (0.45, 1.73)	1.18 (0.57, 2.46)
Both	1.10 (0.72, 1.66)	1.12 (0.68, 1.83)
Total fat mass – DXA % in the third tertile	P=0.810	P=0.645
None	1.00	1.00
Only at 18 years	1.15 (0.60, 2.22)	0.99 (0.43, 2.26)
Only at 22 years	0.89 (0.44, 1.81)	0.89 (0.37, 2.15)
Both	1.20 (0.77, 1.85)	1.35 (0.82, 2.22)
Trunk fat mass – DXA % in the third tertile	P=0.764	P=0.472
None	1.00	1.00
Only at 18 years	1.26 (0.67, 2.37)	1.02 (0.45, 2.34)
Only at 22 years	1.21 (0.64, 2.28)	1.39 (0.66, 2.93)
Both	1.22 (0.78, 1.90)	1.46 (0.88, 2.42)
FMI in the third tertile	P=0.828	P=0.905
None	1.00	1.00
Only at 18 years	1.21 (0.66, 2.22)	1.08 (0.50, 2.32)
Only at 22 years	0.81 (0.40, 1.63)	0.84 (0.37, 1.90)
Both	1.04 (0.68, 1.58)	1.14 (0.70, 1.84)

Notes: The 1993 Pelotas Birth Cohort.

^aLogistic regression (persistent wheezing: wheezing in the last 12 months reported at 18- and 22-year follow-ups – yes/no). Adjusted by gender, skin color, asset index (quintiles), education (years), maternal smoking during pregnancy, parents smoking during infancy, hospitalization during infancy, parents history of asthma, wheezing or bronchitis, household crowding, smoking trajectory 18–22 years, and physical activity trajectory 18–22 years.

Abbreviations: BMI, body mass index; DXA, dualenergy X-ray absorptiometry; FMI, fat mass index.