Table S3.

Adverse pregnancy outcomes in singleton births to women with autism, with psychotropic and antiepileptic medication during pregnancy, Sweden, 2006–2014

Outcome variables		Cases in women with autism (n=1,007)	Cases in population controls (n=67,374)	Crude OR; 95% CI	Adjusted OR;a 95% CI
Preterm birth	Preterm birth, all	71 (7.1)	4,426 (6.6)	1.08; 0.85–1.38	1.02; 0.80–1.30
	Preterm birth <28 weeks	1 (0.1)	183 (0.2)	0.36; 0.05–2.61	0.35; 0.05–2.79
	Preterm birth 28 to <32 weeks	7 (0.7)	399 (0.6)	1.18; 0.56–2.49	1.12; 0.53–2.37
	Preterm birth 32 to <37 weeks	63 (6.3)	3,844 (5.7)	1.10; 0.85–1.43	1.04; 0.80–1.34
	Spontaneous preterm birthb	41 (4.1)	2,408 (3.6)	1.14; 0.84–1.57	1.06; 0.77–1.46
	Medically indicated preterm birthb	29 (2.9)	1,969 (2.9)	0.98; 0.68–1.43	0.95; 0.66–1.38
Mode of delivery	Cesarean delivery	196 (19.5)	15,033 (22.3)	0.84; 0.72–0.98	0.98; 0.84–1.15
	Elective cesarean delivery	106 (10.5)	8,377 (12.4)	0.83; 0.68–1.02	1.02; 0.84–1.26
	Not elective cesarean delivery	90 (8.9)	6,656 (9.9)	0.90; 0.72–1.11	0.94; 0.75–1.17
	Induction of delivery, all	228 (22.6)	12,091 (17.9)	1.34; 1.15–1.55	1.33; 1.14–1.55
Apgar score	Apgar score <7 at 5 minutes	23 (2.3)	1,319 (2.0)	1.17; 0.77–1.78	1.14; 0.75–1.73
Intrauterine growth	SGA	112 (11.2)	6,666 (9.5)	1.14; 1.06–1.51	1.05; 0.86–1.28
	LGA	109 (9.0)	7,396 (9.8)	0.98; 0.80–1.20	1.05; 0.86–1.29
Stillbirth	Stillbirth	1 (0.1)	245 (0.4)	0.27; 0.04–1.94	0.26; 0.04–1.88
Maternal complications	Preeclampsia	47 (4.7)	2,299 (3.4)	1.39; 1.03–1.86	1.29; 0.95–1.74
	Gestational diabetes	13 (1.3)	1,052 (1.3)	0.82; 0.48–1.43	0.99; 0.56–1.72

Notes: Data are n (%) unless otherwise specified. Statistically significant risk estimates are italicized and bold.

^aORs were adjusted for maternal age, country of maternal birth, smoking, body mass index, parity, and year of birth.

^bWe did not have data on spontaneous vs induced preterm birth in all preterm births, hence numbers do not add up.

Abbreviations: LGA, large for gestational age; SGA, small for gestational age.