Figure 6.

In participant NOR076, cSLO NIR reflectance (A) and IRAF (B) images show a small region of variable reflectivity and subtle hypo-AF (arrowheads). The OCT B-scan (C) corresponding to the arrow in (A) shows small bumps in the outer retina (arrows) suggestive of drusen. White boxes in (A, B), and dashed lines in (C) denote the region imaged with AO. Photoreceptors in AO NIR reflectance (D) appear relatively normal, with a cluster of hyporeflective cones near presumed drusen, consistent with the gross appearance in (A). Hyporeflective locations correspond to punctate hyper- and hypo-AF structures in AO IRAF montage (E) disrupting a normal-appearing RPE mosaic. Scale bars: 500 μm for (A, B) and 200 μm (C, vertical and horizontal, D, E).