Table 1.
Epigenetic regulation of MDSCs.
| Epigenetic modulation | Target gene/pathway | Species | References | |
|---|---|---|---|---|
| 1 | DNA MODIFICATIONS | |||
| a | DNA methylation | JAK/STAT | Mice | (63, 64) |
| 2 | HISTONE MODIFICATIONS | |||
| a | Acetylation | |||
| HDAC2 | Retinoblastoma | Mice | (68) | |
| HDAC11 | Not mentioned | Mice | (67) | |
| 3 | POSITIVE REGULATION OF MDSCs (miRNAs) | |||
| a | miR-210 | Arginase-1, CXCL12, IL-16 | Mice | (70) |
| b | miR-9 | Runt-related transcription factor-1 | Mice/Human | (71) |
| c | miR- 494 | PTEN/AKT | Mice | (72) |
| d | miR-690 | CCAAT enhancer binding protein | Mice | (73) |
| e | miR-155, miR-21 | SOCS/SHIP-1/PTEN | Mice | (74) |
| f | miR-17-5p and miR 20a | SHIP-1/PTEN | Mice | (75) |
| g | miR-181b | CYL D,NF-KB | Human | (76) |
| h | miR-34a | N-myc | Chimera | (77) |
| 4 | NEGATIVE REGULATION OF MDSCs (miRNAs) | |||
| a | miR-223 | Myocyte enhancer factor-2(MEFC-2) | Mice | (78) |
| b | miR-424 | PU.1/NFI-A | Human | (79) |
| c | miR-146a | TRAF6/NF-KB/IRAK1 | Mice | (80) |
| 5 | NEGATIVE REGULATION OF MDSCs (siRNAs) | |||
| a | A20 siRNA | A20 | Mice | (81) |
| b | STAT3 siRNA | STAT3-arginase-1 | Human | (82, 83) |
| c | SCF siRNA | Stem cell factor | Mice | (84) |
| d | CK2siRNA | CK2-NOTCH | Mice | (85) |