. 2018 Aug 17;47(6):1910–1937. doi: 10.1093/ije/dyy153

Table 4.

Candidate genes exhibiting associations between nutritional exposures during periconception and pregnancy and offspring DNA methylation. Links between methylation at nutrition-sensitive genes and offspring phenotype are also included

Gene/region of Interest	Genomic features^c	Exposure (↑/↓: increased/decreased)	Outcome (↑/↓: increased/decreased)	Coordinates of ROI in studies^d,e (number of CpGs on 450k^a and EPIC^b arrays)
Blue = ME
Brown = imprinted
Yellow = ME and imprinted
ABCA1 (ATP Binding Cassette Subfamily A Member 1)	Promoter marks; CpG island; binding site for multiple TFs	Famine	↑Methylation⁴⁷	chr9: 107, 690, 502-107, 690, 821 (1)^a(5)^b
ACADM (Acyl-CoA Dehydrogenase, C-4 To C-12 Straight Chain)	Multiple TFs binding sites; Promoter mark; Active Enhancer mark	↑Folate	↑Methylation⁶¹	chr1: 76, 189, 707-76, 190, 008 (6)^a(7)^b
BOLA3 (BolA Family Member 3)	Enhancer and Promoter marks; CpG island; binding site for multiple TFs	Rainy season conception	↑Methylation³⁰	chr2: chr2: 74, 357, 632-74, 357, 837 (1)^a,b
CRH (Corticotropin-Releasing Hormone)	Enhancer mark	↑Choline	↓Methylation⁶⁰	chr8: 67, 090, 692-67, 091, 132 (5)^a(8)^b
CYS1 (Cystin 1)	Multiple TFs binding sites; Promoter mark	↑Folate	↓Methylation⁵⁰	chr2: 10, 220, 719
DNMT1 (DNA Methyltransferase 1)	Multiple TFs binding sites; Promoter mark; Active Enhancer mark	↑Folate	↑Methylation⁴⁴, ↓Methylation⁴²	chr19: 10, 305, 774-10, 305, 811 (2)^a,b
	Multiple TFs binding sites; Promoter mark; Active Enhancer mark	↑Folic acid	↓Methylation⁴⁴	chr19: 10, 305, 774-10, 305, 811 (2)^a,b
	Multiple TFs binding sites; Promoter mark; Active Enhancer mark	↑Choline	↑Methylation⁴⁴, ↑↓Methylation⁴²	chr19: 10, 305, 774-10, 305, 811 (2)^a,b
	Multiple TFs binding sites; Promoter mark; Active Enhancer mark	↑Betaine	↑Methylation⁴²	chr19: 10, 305, 774-10, 305, 811 (2)^a,b
EXD3 (FLJ20433) (exonuclease 3'-5' domain containing 3)	Active Enhancer mark; CpG island	Rainy season conception	↑Methylation³⁰	chr9: 140, 312, 206-140, 312, 339
FAM150B (Family With Sequence Similarity 150, Member B)	None	Famine	↑Methylation⁴⁸	chr2: 366, 113 (1)^a,b
FZD7 (Frizzled Class Receptor 7)	Multiple TFs binding sites; Promoter mark	↑Folate	↑methylation⁶¹	chr2: 202, 901, 045-202, 901, 470 (5)^a(4)^b
GNASAS (Guanine Nucleotide Binding Protein (G Protein), Alpha Stimulating Activity Antisense RNA 1)	Enhancer marks; Multiple TFs binding sites	Famine (periconceptional)/Famine (late gestation)	↑Methylation/ ↓Methylation⁴⁷	chr20: 57, 425, 815-57, 426, 108 (3) ^a,b
	CpG island; MYC binding site	UNIMMAP (supplementation)	↓Methylation⁵³	chr20: 57, 429, 802-57, 430, 242 (1)^a(2)^b
H19	Multiple TFs binding sites	↑Methylation	↑Birthweight⁵⁶	chr11: 2, 011, 131-2, 011, 275 (2)^a,b
	MYC and CTCF binding sites; Active promoter mark; weak enhancer mark	↑Methylation	↑Small for gestational age⁹²	chr11: 2, 019, 727-2, 019, 921 (7)^a(6)^b
	Multiple TFs binding sites	↑ Omega-3 PUFA	↓Methylation⁶⁴	chr11: 2, 024, 197-2, 024, 340
	Multiple TFs binding sites	↑Folic acid	↓Methylation⁵¹	chr11: 2, 024, 254-2, 024, 261
	Enhancer Mark; CTCF-binding site	↑Methylation	↓Birth length, ↑weight in adulthood, ↑adult BMI, ↑adult blood pressure⁶²	chr11: 2, 021, 072-2, 021, 291 (2)^a,b
HSD11B2 (Hydroxysteroid 11-Beta Dehydrogenase 2) (HSD2)	Multiple TFs binding sites; CpG island	↑Methylation	↓Neonatal ponderal index, ↑birthweight, ↑adult adiposity, ↑adult blood pressure⁶²	chr16: 67464346-67464649 (3)^a(4)^b
	Multiple TFs binding sites; Promoter mark; Active Enhancer mark; CpG island	↑Meat and fish intake	↑Methylation⁶²	chr16: 67, 464, 981-67, 465, 111 (1)^a(2)^b
	Multiple TFs binding sites, Active Enhancer mark	↓Methylation	↑Risk of being in a poorly regulated neurobehavioral profile¹⁰³^,¹⁰⁴	chr16: 67, 464, 387-67, 464, 417
IGF2 (Insulin-like Growth Factor 2)	POL2A binding site	↑Folic acid	↓Methylation⁴⁴	chr11: 2, 151, 629-2, 151, 721 (3) ^a,b
	POL2A binding site	↑Folate	↑Methylation⁵⁶	chr11: 2, 151, 629-2, 151, 721 (3) ^a,b
	1 reported SNP (rs3741210)	↑Omega-3 PUFA	↑Methylation⁶⁴	chr11: 2, 169, 425-2, 169, 556
	CTCF binding site; Enhancer mark; 2 reported SNPs (rs3741210, rs3741208)	↑Folic acid	↑Methylation⁵²	chr11: 2, 169, 459 -2, 169, 796
	CTCF binding site; Enhancer mark; 2 reported SNPs (rs3741210, rs3741208)	↑Methylation	↓Birthweight⁵²	chr11: 2, 169, 459 -2, 169, 796
	CTCF binding site; Enhancer mark; 2 reported SNPs (rs3741210, rs3741208)	Famine	↓Methylation⁴⁵^,⁴⁶	chr11: 2, 169, 459-2, 169, 796
	POL2A and USF1 binding sites; 1 CpG island; 1 reported SNP (rs1803647)	↑Folic acid	↑Methylation⁵⁸	chr11: 2, 154, 262-2, 154, 977 (5)^a,b
	Multiple TFs binding sites; Promoter mark; Active Enhancer mark	↑Methylation	↑ADHD in early‐onset persistent youth⁶³	(37)^a(35)^b,f
	Multiple TFs binding sites; Promoter mark; Active Enhancer mark	High‐fat and ‐sugar diet	↑Methylation⁶³	(37)^a(35)^b,f
	POL2A binding site; Promoter mark; Active Enhancer mark; CpG island	↑Omega-3 PUFA	↑Methylation⁶⁴	chr11: 2, 159, 107-2, 159, 965 (3)^a(4)^b
	EZH2 and CTCF binding site; Promoter mark; CpG island	↑Vitamin B12	↓Methylation⁵⁹	chr11: 2, 161, 115-2, 161, 275 (4)^a,b
	CTCF binding site; Enhancer mark; 2 reported SNPs (rs3741210, rs3741208)	Famine	↓Methylation⁴⁶	chr11: 2, 169, 385-2, 169, 489
	Enhancer mark	Famine	↓Methylation⁴⁶	chr11: 2, 170, 541-2, 170, 644
	CTCF binding site; Enhancer mark; 2 reported SNPs (rs3741210, rs3741208)	↓Methylation	↑Small for gestational age⁸³	chr11: 2, 169, 458-2, 169, 796
	EZH2, RAD21 and CTCF binding site; Promoter mark; CpG island	Famine	↑Methylation⁴⁶	chr11: 2, 160, 906-2, 161, 372 (14)^a(13)^b
	EZH2, ZBTB7A and CTCF binding site; Promoter mark; CpG island	Famine	↑Methylation⁴⁶	chr11: 2, 161, 550-2, 161, 846 (1)^a(2)^b
	Enhancer mark; 1 reported SNPs (rs3741210)	↓Methylation	↑Small for gestational age⁹⁵	chr11: 2, 169, 467-2, 169, 640
	POLR2A and ZBTB7A binding site	Famine	↓Methylation⁴⁶	chr11: 2, 155, 447-2, 155, 736 (1)^a,b
	CpG island; USF1 and POL2A binding sites	↑Methylation	↑Birthweight, birth height, head and thorax circumference at birth⁹¹	chr11: 2, 154, 263-2, 154, 457 (2)^a,b
	None	↑Methylation	↑Birthweight⁹⁰	chr11: 2, 169, 518-2, 169, 499
	CTCF and REST binding sites; CpG island	↑Methylation	↑TG and TG: HDL¹⁰²	chr11: 2, 160, 374-2, 160, 610 (4)^a,b
IGF2R (Insulin-like Growth Factor 2 Receptor)	CpG island; associated with SNP rs677882 and rs8191722	↑UNIMMAP (supplementation)	↓Methylation⁵³	chr6: 160, 426, 403-160, 426, 850
IGF2/H19 ICR	None	↑Methylation	↓Head circumference between 1–10 years; ↑subcutaneous fat measures at age 17 years⁹⁷	chr11: 2, 064, 402-2, 064, 717
IL10 (Interleukin 10)	Enhancer and Promoter marks; binding site for multiple TFs	Famine	↑Methylation⁴⁷	chr1: 206, 946, 011-206, 946, 339 (2)^a(3)^b
INSIGF (Insulin- Insulin-like Growth Factor 2)	None	Famine	↓Methylation⁴⁶^,⁴⁷	chr11: 2, 182, 336-2, 182, 640 (5)^a(4)^b
LASP1 (LIM And SH3 Protein 1)	Multiple TFs binding sites; Promoter marks; Enhancer marks; 4 CpG islands; 25 reported SNPs	↑Folate	↑Methylation⁶¹	chr17: 37, 123, 638-37, 123, 949 (9)^a,b
LEP (Leptin)	None	↑Folate	↓Methylation⁴²^,⁴⁴	chr7: 127, 881, 035-127, 881, 054
	None	↑Betaine	↓Methylation⁴²	chr7: 127, 881, 035-127, 881, 054
	None	↑Folic acid	↑Methylation⁴²	chr7: 127, 881, 035-127, 881, 054
	CpG island; CEBP binding site; 2 reported SNPs (rs791620, rs2167270)	Famine	↑Methylation⁴⁷	chr7: 127, 881, 054-127, 881, 410 (4)^a(6)^b
	CpG island; CEBP binding site; 2 reported SNPs (rs791620, rs2167270)	↑Methylation	↑Small for gestational age⁹⁴	chr7: 127, 881, 127-127, 881, 350 (4)^a(6)^b
	CpG island; 1 reported SNP (rs2167270)	↓Methylation	↑BMI¹⁰⁰	chr7: 127, 881, 280-127, 881, 300 (2)^a(3)^b
	CpG island; CEBP binding site; 2 reported SNPs (rs791620, rs2167270)	↓Methylation	↑BMI; ↑hip circumference⁹⁸	chr7: 127, 881, 126-127, 881, 474 (3)^a(4)^b
	CpG island; CEBP binding site; 2 reported SNPs (rs791620, rs2167270)	↑Methylation	↑Fasting LDL-C⁹⁸	chr7: 127, 881, 126-127, 881, 474 (3)^a(4)^b
	CpG island	↓Methylation	↑BMI⁹⁹	chr7: 127, 881, 036 -127, 881, 057
	CpG island; CEBP binding site; 2 reported SNPs (rs791620, rs2167270)	↑Methylation	↑Lethargy and hypotonicity¹⁰⁵	chr7: 127, 881, 127-127, 881, 350 (4)^a(6)^b
	CpG island; CEBP binding site; 2 reported SNPs (rs791620, rs2167270)	↓Methylation	↑HDL¹⁰¹	chr7: 127, 881, 053-127, 881, 410 (4)^a(6)^b
LY6E (Lymphocyte Antigen 6 Family Member E)	Multiple TFs binding sites; Promoter mark; Active Enhancer mark	↑Folate	↓Methylation⁶¹	chr8: 144, 120, 106-144, 120, 706 (8)^a(9)^b
MEG3 (Maternally Expressed 3) (GTL-2)	CpG island; Promoter mark	↑Vitamin B6	↑Methylation⁵⁴	chr14: 101, 294, 220-101, 294, 391
	CpG island; Promoter mark	↑Folate	↓Methylation⁵⁶	chr14: 101, 294, 220-101, 294, 391
	Enhancer and Promoter marks; CpG island; POLR2A binding site	↑ UNIMMAP (supplementation)	↓Methylation⁵³	chr14: 101, 292, 283– 101, 292, 796 (4)^a(5)^b
	CpG island; Promoter mark	↓Methylation	↑Birthweight⁵⁶	chr14: 101, 294, 220-101, 294, 391
	None	Famine	↑Methylation⁴⁷	chr14: 101, 291, 413-101, 291, 642 (5)^a(6)^b
MEST (Mesoderm-Specific Transcript) (PEG1)	CpG island	↑UNIMMAP (supplementation)	↓Methylation⁵³	chr7: 130, 131, 325-130, 131, 792 (11)^a(9)^b
MEST (Mesoderm-Specific Transcript) (PEG1)	Multiple TFs binding sites; Promoter mark; Enhancer mark; CpG island	↑Methylation	↑Small for gestational age⁹³	chr7: 130, 125, 200-130, 126, 400 (16)^a(17)^b
MIRLET7BHG (MicroRNA Let-7b Host Gene)	Active Enhancer mark	↑Omega-6 PUFA	↓Methylation⁶⁶	chr22: 46, 473, 721 (1)^a,b
MIRLET7BHG (MicroRNA Let-7b Host Gene)	Active Enhancer mark	↓Methylation	↑Birthweight⁶⁶	chr22: 46, 473, 721 (1)^a,b
NR3C1 (Nuclear Receptor Subfamily 3 Group C Member 1) (GR)	Multiple TFs binding sites; Promoter mark; Enhancer mark; CpG island; 2 reported SNPs (rs10482604, rs10482605)	↑Methylation	↑Risk of being in a poorly regulated neurobehavioural profile¹⁰³^,¹⁰⁴	chr5: 142, 783, 501-142, 783, 640 (4)^a,b
	Multiple TFs binding sites; Promoter mark; Enhancer mark; CpG island; 2 reported SNPs (rs10482604, rs10482605)	↑Choline	↑Methylation⁶⁰	chr5: 142, 783, 501-142, 783, 908 (5)^a(7)^b
	Multiple TFs binding sites; Promoter mark; Enhancer mark; CpG island	↑Methylation	↑Adult waist circumference, ↑adult BMI⁶²	chr5: 142, 782, 759-142, 783, 164 (2)^ab
	Multiple TFs binding sites; Promoter mark; Enhancer mark; CpG island; 1 reported SNP (rs10482604)	↑Meat/fish and vegetable intake, ↓bread/potato intake in late pregnancy	↑Methylation⁶²	chr5: 142, 783, 579-142, 783, 714 (3)^a,b
	Multiple TFs binding sites; Promoter mark; Enhancer mark; CpG island; 1 reported SNP (rs10482604)	↑Methylation	↓Adult blood pressure⁶²	chr5: 142, 783, 578 -142, 783, 714 (3)^a,b
OSBPL5/MRGPRG (Oxysterol-Binding Protein Like 5/MAS Related GPR Family Member G)	Enhancer mark; CpG island	Famine	↓Methylation⁴⁸	chr11: 3, 225, 076 (1)^a,b
OTX2 (Orthodenticle Homeobox 2)	CpG island; EZH2 binding site	↑Folate	↓Methylation⁵⁰	chr14: 57, 278, 729 (1)^a,b
PAX8 (Paired Box⁸)	Multiple TFs binding sites; Promoter mark; Active Enhancer mark	Rainy season conception	↑Methylation³⁰	chr2: 113, 993, 262-113, 993, 391(2)^a,b
		Rainy season conception	↑Methylation³⁰	chr2: 113, 992, 866-113, 993, 036(2)^a,b
	Multiple TFs binding sites; Promoter mark; Active enhancer mark	Famine	↑Methylation⁴⁹	chr2: 113, 992, 762-113, 993, 313 (8)^a(7)^b
PEG3 (Paternally Expressed 3)	Multiple TFs binding sites; 2 CpG islands; 1 reported SNP (rs2302376)	↑Folate	↓Methylation⁵⁶	chr19: 57, 351, 945-57, 352, 096 (4)^a(3)^b
	Multiple TFs binding sites; 2 CpG islands; 1 reported SNP (rs2302376)	↑Folic acid	↓Methylation⁵⁶	chr19: 57, 351, 945-57, 352, 096 (4)^a(3)^b
	Multiple TFs binding sites; 2 CpG islands; 1 reported SNP (rs2302376)	↑Folic acid	↓Methylation⁵⁸	chr19: 57, 351, 944-57, 352, 096 (4)^a(3)^b
PLAGL1 (PLAG1-Like Zinc Finger 1) (ZAC1)	Multiple TFs binding sites; Promoter mark; Active Enhancer mark; CpG island	↑Folate	↓Methylation⁵⁶	chr6: 144, 329, 109-144, 329, 231 (1)^a,b
	Multiple TFs binding sites; Promoter mark; Active Enhancer mark; CpG island	↑Methylation	↑Birthweight⁵⁶	chr6: 144, 329, 109-144, 329, 231 (1)^a,b
	Multiple TFs binding sites; Promoter mark; CpG island	↑Methylation index	↑Fetal weight at 32 weeks of gestation, weight and BMI at 1 year⁴⁰	chr6: 144, 329, 390-144, 329, 740 (4)^a,b
	Multiple TFs binding sites; Promoter mark; CpG island	↑ Vitamin B2	↑Methylation index⁴⁰	chr6: 144, 329, 390-144, 329, 740 (4)^a,b
POMC (Proopiomelanocortin)	Multiple TFs binding sites; Promoter mark; Active Enhancer mark; CpG island	↑Methylation	↑BMI⁴³^,⁹⁶	chr2: 25, 384, 508-25, 384, 832 (3)^a,b
POMC (Proopiomelanocortin)	Multiple TFs binding sites; Promoter mark; Active Enhancer mark; CpG island	↑SAM:SAH ratio; ↑betaine	↑Methylation⁴³	chr2: 25, 384, 508-25, 384, 832 (3)^a,b
PPAP2C (PLPP2) (Phosphatidic Acid Phosphatase 2c)	CpG island	Famine	↑Methylation⁴⁸	chr19: 292, 167 (1)^a,b
PRDM9 (PR-Domain Containing Protein 9)	Multiple transcription factor binding sites; Promoter mark, Active enhancer mark; 2 reported SNPs (rs10077095, rs1994929)	Famine	↓Methylation⁴⁹	chr5: 23, 507, 030-23, 507, 752 (12)^a(11)^b
RBM46 (RNA-Binding Motif Protein 46)	CpG island	Rainy season conception	↑Methylation³¹	chr4: 155, 702, 818-155, 703, 110 (1)^a,b
RXRA (Retinoid X Receptor Alpha)	Multiple TFs binding sites; Enhancer mark	↑Methylation	↑Fat mass; % fat mass⁵⁵	chr9: 137, 215, 697 -137, 216, 117 (1)^a,b
	Multiple TFs binding sites; Enhancer mark	↑Methylation	↑BMI⁵⁵	chr9: 137, 215, 697 -137, 216, 117 (1)^a,b
	Multiple TFs binding sites; Enhancer mark	↑Carbohydrate intake	↓Methylation⁵⁵	chr9: 137, 215, 697 -137, 216, 117 (1)^a,b
	Multiple TFs binding sites; Enhancer mark	↑Methylation	↓Bone mineral content; % BMC⁷⁵	chr9: 137, 215, 697 -137, 216, 117 (1)^a,b
	Multiple TFs binding sites; Promoter mark; Active Enhancer mark; CpG island	↑Folate	↓Methylation⁴²	chr9: 137, 217, 097-137, 217, 132
	Multiple TFs binding sites; Promoter mark; Active Enhancer mark; CpG island	↑Folate	↑Methylation⁴⁴	chr9: 137, 217, 097-137, 217, 132
SLC38A2 (Solute Carrier Family 38 Member 2)	Enhancer mark	Famine	↑Methylation⁴⁸	chr12: 46, 737, 123 (1)^a,b
SLITRK1 (SLIT And NTRK-like Family Member 1)	Promoter mark; Enhancer mark; CpG island	Rainy season conception	↑Methylation³⁰	chr13: 84, 453, 741-84, 453, 828
SLITRK1 (SLIT And NTRK-like Family Member 1)	Promoter mark; Enhancer mark; CpG island	Rainy season conception	↑Methylation³⁰	chr13: 84, 454, 210-84, 454, 281
SPATC1L (C21orf56) (Spermatogenesis And Centriole Associated 1 Like)	Multiple TFs binding sites; Promoter mark; Active Enhancer mark	↑Folate	↓Methylation⁶¹	chr21: 47, 604, 052-47, 604, 654 (5)^a,b
STX11 (Syntaxin 11)	Multiple TFs binding sites; Promoter mark; CpG island	↑Folate	↓Methylation⁵⁰	chr6: 144, 471, 564 (1)^a,b
TACC1 (Transforming Acidic Coiled-Coil Containing Protein 1)	Promoter mark; Enhancer mark	Famine	↑Methylation⁴⁸	chr8: 38, 586, 183 (1)^a,b
TFAP2A (Transcription Factor AP-2 Alpha)	E2F1 and EZH2 binding site; Promoter mark; Active Enhancer mark; CpG island	↑Folate	↓Methylation⁵⁰	chr6: 10, 411, 911 (1)^a,b
TMEM105 (Transmembrane Protein 105)	Enhancer mark; Active Enhancer mark; CpG island	Famine	↓Methylation⁴⁸	chr17: 79, 283, 915 (1)^a,b
VTRNA2-1 (Vault RNA 2-1)	Multiple TFs binding sites; Promoter mark; Active Enhancer mark; CpG island	Rainy Season; ↑vitamin B2; ↑methionine; ↓dimethylglycine	↑Methylation⁴¹	chr5: 135, 415, 762-135, 416, 613 (15)^a(13)^b
WNT9A (Wnt Family Member 9A)	NRF1 binding site; Promoter mark; Active Enhancer mark; CpG island	↑Folate	↑Methylation⁶¹	chr1: 228, 075, 423-228, 075, 749 (5)^a(3)^b
ZFP57 (Zinc Finger Protein 57)	YY1 binding site; Promoter mark; Active Enhancer mark; multiple reported SNPs	↑Folate	↓Methylation⁶¹	chr6: 29, 648, 161-29, 649, 084 (24)^a(25)^b
ZFP57 (Zinc Finger Protein 57)	Promoter mark; Active Enhancer mark; multiple reported SNPs	Famine	↓Methylation⁴⁹	chr6: 29, 648, 345-29, 649, 024 (19)^a(18)^b
ZFYVE28 (Zinc Finger FYVE-Type Containing 28)	Multiple TFs binding sites; Promoter mark; CpG island	Rainy season conception	↑Methylation³⁰	chr4: 2, 366, 658-2, 366, 739 (1)^a,b
ZFYVE28 (Zinc Finger FYVE-Type Containing 28)	Multiple TFs binding sites; Promoter mark; CpG island	Rainy season conception	↑Methylation³⁰	chr4: 2, 366, 909-2, 367, 003
ZNF385A (Zinc Finger Protein 385A)	Multiple TFs binding sites; Promoter mark; CpG island	Famine	↑Methylation⁴⁸	chr12: 54, 764, 265 (1)^a,b

LBW, low birthweight; LDL-C, low-density lipoprotein cholesterol; ME, metastable epiallele; ROI, region of interest; SAH, s-adenosyl homocysteine; SAM, s-adenosyl methionine; UNIMMAP, United Nations International Multiple Micronutrient Preparation.

Number of CpGs covered on Infinium HumanMethylation450K BeadChip array.

Number of CpGs covered on Infinium MethylationEPIC array.

The following regulatory features were checked: enhancer/promoter marks (histone), overlapping binding sites for various transcription factors (e.g. CTCF, POL2A etc.) within region of interest (ROI) and presence of nearby reported GWAS single nucleotide polymorphisms (SNPs).

Coordinates based on genome build hg19. The BiSearch Web server¹²² was used to find genomic coordinates for ROIs where only primers were available.

HumanMethylation450 v1.2 and Infinium MethylationEPIC v1.0 B4 Manifest Files were referred to report ROI coverage on Illumina Infinium Methylation BeadChip arrays.

A total of 37 probes from 450k array were found within the gene and considered for analysis.