Fig. 3.

Levels of compleasome complex in cerebrospinal fluid (CSF) samples from herpes simplex encephalitis (HSE) patients over time (n = 13). The complex was measured with sandwich enzyme-linked immunosorbent assay (ELISA) using monoclonal antibody (mAb) against proteasome subunit 20Sα6 and polyclonal antibody (pAb) against complement factor 3 (C3) and is presented in relation to day of onset of neurological symptoms. Between two and ten samples of individual patients from different time points (collected 0–523 days after symptom onset) are presented. The inset shows a detailed graph of the CSF samples collected after 0–30 days. Median levels of compleasome complex in CSF of healthy controls (HCs) (n = 23) are indicated with a dotted line and of patient controls (PCs) (n = 27) with the dashed line