Table 4.
Geometric mean trough plasma concentrations of afatinib after multiple daily dosing of afatinib 40 mg and after dose escalation to afatinib 50 mg or dose reduction to afatinib 30 mg
| Visit | Afatinib 30 mg
|
Afatinib 40 mg
|
Afatinib 50 mg
|
||||||
|---|---|---|---|---|---|---|---|---|---|
| N | gMean, ng/mL | gCV, % | N | gMean, ng/mL | gCV, % | N | gMean, ng/mL | gCV, % | |
| Course 2 visit 1 (day 22) | 0 | NE | NE | 187 | 22.6 | 60.9 | 0 | NE | NE |
| Course 2 visit 2 (day 29) | 6 | 19.5 | 90.3 | 143 | 23.5 | 63.0 | 33 | 23.3 | 60.6 |
| Course 3 visit 1 (day 43) | 17 | 20.6 | 47.1 | 140 | 21.5 | 63.5 | 34 | 23.5 | 61.5 |
Abbreviations: gCV, geometric coefficient of variation; gMean, geometric mean; NE, not evaluable.