Table 4.
Induction of breast cancer in mice with low-LET ionising radiation
| Malignancy | Mouse strain | Age | Sex | Dosage | Fractionation | Latency | Spontaneous frequency | Induced frequency | Ref. |
|---|---|---|---|---|---|---|---|---|---|
| Breast cancer | BALB/c | 12 weeks | Female | 2.0 Gy TBI | Single | ~24 months | 8% | 22% | (237) |
| Breast cancer | BALB/c orthograft | 12 weeks | Female | 1.0 Gy TBI of donor cells | Single | 10 weeks | <1% | Dysplasia ~75% Tumors ~25% (dependent upon donor cell passage) |
(271) |
| Breast cancer | BALB/c chimera | 12 weeks | Female | 4.0 Gy TBI of host | Single | 6 weeks | ~19% | ~81% | (30) |