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. 2016 Jun 24;75(8):779–790. doi: 10.1093/jnen/nlw056

FIGURE 8.

FIGURE 8.

The percentage of BIN1-immunoreactive (-ir) CA1 pyramidal neurons correlates positively with CERAD hippocampal neuritic plaque score but not with tangled neuron fraction. (A) The percentage of BIN1-ir neurons does not correlate with the percentage of tangled neurons in CA1 region. As expected, the fraction of tangled neurons negatively correlates with the total number of pyramidal neurons in CA1. (B) Hippocampal CERAD neuritic (N) plaque scores correlates positively with the percentage of BIN1-ir neurons in CA1. Diffuse (D) plaque score does not correlate. Symbols indicate subject group: (•) CDR0, BB0; (▪) CDR0-0.5, BBII-III; (▲) CDR1-2, BBIV-V.