Fig 1.

Clinical manifestations and biochemical analysis of patient P1. A and B, Dermatologic signs evolved from the initial presentation of urticaria-like rash (Fig 1, A) to petechiae and ecchymosis (Fig 1, B). C and D, Ultrasonographic images indicate hepatomegaly (Fig 1, C) and splenomegaly (Fig 1, D). E and F, Increased C-reactive protein (CRP) levels (Fig 1, E) and platelet counts (Fig 1, F) were improved transiently with intravenous immunoglobulin and dexamethasone. G and I, Ferritin levels (Fig 1, G) remained markedly increased despite treatment with numerous immunomodulatory agents (Fig 1, I). H, Acute renal injury and response to peritoneal dialysis monitored with serum creatinine levels. J, Serum IL-18, IL-18BP, and free IL-18 levels were assessed on days 12 and 35. PRBC, Packed red blood cells.