Table 4.
Outcomes stratified by Day3-AKI
| Category | Overall | No AKI | AKI | P-value (no AKI versus AKI) | |
|---|---|---|---|---|---|
| Demographics | n (%) | 156 | 141 (90.4) | 15 (9.6) | — |
| Male (%) | 98 (52.7) | 71 (50.4) | 11 (73.3) | ns | |
| Age (years) | 8.4 (2.7, 15.5) | 8.2 (2.7, 15.1) | 12.8 (2.9, 18.0) | ns | |
| Day0 PRISM-III | 8 (3, 14) | 7 (3, 13) | 15 (11, 23) | <0.001 | |
| Day0 renal angina | 52 (33.3) | 40 (28.4) | 12 (80) | χ 2 = 16.2, P < 0.001 | |
| Sepsis Dx (%) | 41 (26.3) | 31 (21.9) | 10 (66.7) | χ 2 = 13.9, P < 0.001 | |
| Transplant history (%) | 20 (12.8) | 13 (9.2) | 7 (46.7) | χ 2 = 17.1, P < 0.001 | |
| Outcomes | Mechanical Vent days | 2 (0, 7) | 2 (0, 6) | 6 (3, 15) | 0.03 |
| CRRT use (%) | 6 (85.7) | 0 | 6 (100) | χ 2 = 48.8, P < 0.001 | |
| Organ failure days | 3 (1, 8) | 3 (1, 7) | 7 (3, 16) | 0.03 | |
| Hospital LOS (days) | 17 (8, 34) | 16 (8, 30) | 38 (16, 69) | 0.02 | |
| ICU LOS (days) | 6 (3, 12) | 6 (3, 12) | 8 (6, 18) | 0.02 | |
| Mortality (%) | 9 (7.1) | 6 (4) | 3 (20) | χ 2 = 7.4, P = 0.007 |
Patients in AKI-CHERUB remaining in the ICU on Day3 of admission to the PICU dichotomized by the presence or the absence of severe AKI on Day3 of ICU admission. All values are expressed as medians with interquartile ranges except where designated. n, sample size; AKI by SCr-KDIGO 2–3, AKI diagnosed by change in SCr from baseline per the KDIGO Staging Criteria Stages 2–3; Dx, diagnosis; Vent, ventilation; CRRT, continuous renal replacement therapy; LOS, length of stay; ns, not significant.