Table 5.

Association of combination opioid/acetaminophen preparations, pure opioids, other acetaminophen medications with acute coronary heart disease, cardiovascular death, stroke

	All participants
	Acute CHD		Stroke		Cardiovascular death
	Events n/users, n	aHR (95%CI)	Events n/users, n	aHR (95%CI)	Events n/users, n	aHR (95%CI)
Opioid + Acetaminophen preparation users	53/872	1.14 (0.86–1.52)	35/872	1.40 (0.98–1.99)	56/872	1.41 (1.07–1.86)
Opioid alone preparation users	54/1035	0.89 (0.67–1.17)	22/1034	0.76 (0.50–1.18)	51/1035	1.04 (0.78–1.39)
Other Acetaminophen users	116/2462	0.96 (0.79–1.17)	71/2460	1.06 (0.82–1.35)	85/2462	0.81 (0.64–1.01)
Nonusers of both		REF		–		–
	Females		Females		Females
Opioid + Acetaminophen preparation users	39/587	1.72 (1.22–2.44)	22/587	1.33 (0.85–2.09)	45/587	2.12 (1.52–2.94)
Opioid alone preparation users	28/640	1.12 (0.75–1.65)	11/640	0.63 (0.34–1.16)	28/640	1.22 (0.82–1.81)
Other Acetaminophen users	64/1656	1.22 (0.93–1.59)	42/1665	1.06 (0.76–1.47)	47/1656	0.93 (0.68–1.21)
Nonusers of both		REF		–		–
	Males		Males		Males
Opioid + Acetaminophen preparation users	14/285	0.61 (0.36–1.04)	13/285	1.42 (0.81–2.51)	11/285	0.61 (0.33–1.11)
Opioid alone preparation users	26/395	0.73 (0.49–1.09)	11/394	0.92 (0.50–1.70)	23/395	0.89 (0.57–1.34)
Other Acetaminophen users	52/806	0.79 (0.59–1.05)	29/805	1.04 (0.71–1.52)	38/806	0.72 (0.52–1.01)
Nonusers of both		REF		–		–

Abbreviations: aHR = fully adjusted hazards ratio; CI = confidence interval; CHD = coronary heart disease; REF = referent group.

Bold P < 0.0.5