Table 2.

Proteins reported to partner with menin

Functional categories and protein partners
Transcription
Transcription factors
JUND
c-MYB
NFκB – p50, p52, p65
PEM
RUNX2 (BMP2 signaling)
SMADs – SMAD1, SAMD3, SMAD5 (TGFβ signaling)
TCF3/TCF4/β-catenin (Wnt signaling)
VDR, RAR, PPARγ, ERα (nuclear hormone receptors)
Chromatin modification
HDACs/mSIN3A
LEDGF
MLL1/MLL2 (H3K4me3)
(ASH2L/hDPY30/HCF-2/MLL/RBBP5/RPB2/WDR5 complex)
Transcription initiation or elongation
RNAPII isoforms (pSer5 and pSer2)
SKIP/c-MYC (HIV-1 Tat:P-TEFb transcription)
DNA repair
ASK
CHES1
FANCD2
RPA2
Mutant-protein degradation
CHIP
Signaling mediators in the cytoplasm
AKT1
FOXO1
NM23β
Cytoskeleton/cell division/adhesion/motility
GFAP
IQGAP1
NMMHC-IIA
Vimentin