Table 1. Baseline characteristics upon ICU admission of patients with pneumonia evoked ARDS stratified for AQP5 -1364A/C genotypes (n = 136).
| Variable | AA n = 93 |
AC/CC n = 43 |
P-value |
|---|---|---|---|
| Age yrs. (range/± SD) | 43.9 (18-77/±15.8) | 43.4 (18-66/±13.8) | 0.866 |
| Male gender | 55 (59%) | 24 (56%) | 0.715 |
| Body-mass-index (kg/m2) | 26.7 (±6.6) | 25.9 (± 6.2) | 0.558 |
| ARDS severity * | 0.489 | ||
| - mild | 17 (18%) | 9 (21%) | |
| - moderate | 27 (29%) | 16 (37%) | |
| - severe | 49 (53%) | 18 (42%) | |
| Organ function assessment | |||
| Renal | |||
| - Creatinine concentration (mg/ml) | 1.53 [0.97–2.94] | 1.39 [1.00–1.93] | 0.204 |
| - Cont. hemofiltration/dialysis | 47 (51%) | 18 (42%) | 0.346 |
| - AKI stage 1 | 10 (11%) | 4 (9%) | 0.806 |
| - AKI stage 2 | 23 (25%) | 14 (33%) | |
| - AKI stage 3 | 21 (23%) | 8 (19%) | |
| Circulatory | |||
| - Mean arterial pressure (mmHg) | 76 [68–88] | 82 [72–88] | 0.178 |
| - Cardiac index (L/min/m2) | 4.1 [2.9–4.9] | 3.8 [3.2–4.8] | 0.763 |
| - Vasopressor support (n/%) | 79 (85%) | 34 (79%) | 0.395 |
| - Inotropic support (n/%) | 36 (39%) | 14 (33%) | 0.489 |
| - ECMO therapy (n/%) | 23 (25%) | 14 (33%) | 0.340 |
| Respiratory | |||
| - Mean airway pressure (mmHg) | 28 [24–31] | 27 [22–31] | 0.441 |
| - Lung compliance (ml/mbar) | 29 [20–41] | 28 [18–41.5] | 0.854 |
| - Horowitz index (paO2/FiO2) | 89.5 [68–137] | 113 [85–179] | 0.129 |
| - Lung injury score | 3.3 (±0.5) | 3.3 (±0.5) | 0.867 |
| Inflammatory | |||
| - C-reactive protein concentration (mg/dl) | 20.3 [14.8–27.4] | 18.5 [8,5–23.8] | 0.091 |
| - Procalcitonin concentration (ng/ml) | 10.4 [1.0–55.5] | 5.0 [1.0–29.0] | 0.324 |
| - Leukocyte concentration (*109/l) | 14.0 [9.0–23.1] | 16.1 [11.4–23.3] | 0.283 |
| Hepatic | |||
| - Total bilirubin concentration (mg/dl) | 1.0 [0.6–2.0] | 0.9 [0.5–1.8] | 0.633 |
| - AST (U/l) | 62 [33–157] | 49 [31–114] | 0.326 |
| - ALT (U/l) | 36 [19–74] | 31 [19–75] | 0.872 |
| Organ dysfunction scores | |||
| - SAPS II | 51.7 (±17.2) | 49.9 (±15.9) | 0.566 |
| - SOFA | 13.4 (±4.9) | 13.8 (±6.1) | 0.716 |
| Outcome | |||
| - ICU stay (days) | 27.0 [±25.8] | 25.0 [±14.6] | 0.631 |
| - Duration of mechanical ventilation (days) | 14.6 [±9.1] | 16.4 [±8.3] | 0.271 |
| - Ventilator free days | 9.5 (±9.6) | 10.7 (±9.0) | 0.504 |
| - RRT free days | 7.7 (±9.4) | 10.6 (±9.3) | 0.099 |
| - 30-days mortality | 35 (37.6%) | 6 (13.9%) | 0.005 |
Data are presented as n (%); means (± SD), and medians (25th, 75th percentile)
*ARDS severity was stratified according to Berlin definition [16]
ECMO: extracorporeal membrane oxygenation; Horowitz index: paO2/FiO2; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; SAPS II: Simplified Acute Physiology Score; SOFA: Sepsis-related Organ Failure Assessment score, RRT: Renal replacement therapy