Table 1. Demographics and clinical characteristics of the study population.
| Healthy (N = 66) | Glaucoma (N = 58) | P value | |
|---|---|---|---|
| Age (years), median (IQR) | 55 (51–61.8) | 60 (54–62) | 0.077 |
| Left eye, no. (%) | 33 (50.0) | 28 (48.3) | 0.859 |
| Female gender, no. (%) | 41 (62.1) | 28 (48.3) | 0.148 |
| Ethnicity (White; Black; Mixed; Asian), no. (%) | 39 (59.1); 14 (21.2); 12 (18.2); 1 (1.5) | 20 (34.5); 21 (24.5); 17 (29.3); 0 | 0.030 |
| VA (logMAR), median (IQR) | 0 (0) | 0.05 (0–0.1) | 0.001 |
| SE (D), median (IQR) | 0.25 (-0.25 to + 0.75) | 0.25 (-0.25 to +1.5) | 0.180 |
| IOP (mmHg), median (IQR) | 13.0 (11–14) | 13.5 (12–14.8) | 0.062 |
| Medications, median (IQR) | 0 | 3 (2–4) | <0.001 |
| SAP MD (dB), median (IQR) | -0.65 (-1.6 to 0) | -3.44 (-6.0 to -2.4) | <0.001 |
| SAP PSD (dB), median (IQR) | 1.84 (1.5–2.2) | 4.31 (2.8–6.0) | <0.001 |
| FDT MD (dB), median (IQR) | -0.50 (-1.2 to 0.4) | -3.27 (-5.0 to -1.9) | <0.001 |
| FDT PSD (dB), median (IQR) | 3.87 (3.2–4.3) | 5.41 (4.6–6.9) | <0.001 |
| SAPrgc (x1000 cells), median (IQR) | 1151 (1045–1263) | 857 (688–944) | <0.001 |
| OCTrgc (x1000 cells), median (IQR) | 939 (845–1071) | 589 (484–746) | <0.001 |
| WRGC (x1000 cells), median (IQR) | 939 (855–1070) | 622 (536–753) | <0.001 |
| CSFI (%), median (IQR) | 4.5 (-4.1 to 15.4) | 36.9 (27.4 to 44.8) | <0.001 |
| Glaucoma specialist likelihood scale, median (IQR) | 4 (3–5.8) | 13.5 (9.3–15) | <0.001 |
| General ophthalmologist likelihood scale, median (IQR) | 4 (4–8) | 12 (9–14) | <0.001 |
IQR = interquartile range; VA = visual acuity; SE = spherical equivalent; D = diopters; dB = decibels; SAP = standard automated perimetry; FDT = frequency doubling technology; MD = mean deviation; PSD = pattern standard deviation; SAPrgc = SAP-derived estimate of total number of retinal ganglion cells; WRGC = weighted number of retinal ganglion cells based on OCT and SAP measurements; OCTrgc = OCT-derived estimate of total number of retinal ganglion cells; CSFI = combined structure-function index.