Table 1.

Estimation of AIPs in branched pathway model

	ODE Decomposition	Two-phase estimation
		0.01%a	0.1%a	1%a
Computational time (s)b	3968.33	3741.86 (3823.77)c	2042.40	810.37
Number of stiff simulations	203	0	0	0
Average parameter error (%)	0.24	1.37 (0.20)c	2.26	8.11
Slope errord	2.6435	2.4374 (0.0087)c	2.6052	6.6401
Concentration errore	0.0047	0.0187 (0.0049)c	0.0198	0.0805

^aConvergence criterion between two estimation phases.

^bComputational times were based on Dual Processors Intel Quad-Core 2.83 GHz.

^cEvaluated using actual slope values from the ODEs.

^dSlope error is calculated using Equation (4), in which X_u , X_m are simulated using coupled ODEs.

^eConcentration error is calculated using Equation (5), in which X_m are simulated using coupled ODEs.