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. 2011 May 9;27(14):1964–1970. doi: 10.1093/bioinformatics/btr293

Table 1.

Estimation of AIPs in branched pathway model

ODE Decomposition Two-phase estimation
0.01%a 0.1%a 1%a
Computational time (s)b 3968.33 3741.86 (3823.77)c 2042.40 810.37
Number of stiff simulations 203 0 0 0
Average parameter error (%) 0.24 1.37 (0.20)c 2.26 8.11
Slope errord 2.6435 2.4374 (0.0087)c 2.6052 6.6401
Concentration errore 0.0047 0.0187 (0.0049)c 0.0198 0.0805

aConvergence criterion between two estimation phases.

bComputational times were based on Dual Processors Intel Quad-Core 2.83 GHz.

cEvaluated using actual slope values from the ODEs.

dSlope error is calculated using Equation (4), in which Xu , Xm are simulated using coupled ODEs.

eConcentration error is calculated using Equation (5), in which Xm are simulated using coupled ODEs.