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. 2016 Sep 15;25(22):4898–4910. doi: 10.1093/hmg/ddw313

Figure 4.

Figure 4.

Functional analysis of RHOX mutations. (A) Immunofluorescent staining of HEK293 cells after 48h of transfection with RHOXF1 c.515G > A, c.522C > T and (B) RHOXF2/2B c.202G > A, c.411C > T, c.679G > A, and c.381dupG expression vectors. GFP signal reflects RHOX expression, nuclei were counterstained with Hoechst. Scale bar: 50 μm. (C) Gene expression levels of RHOXF1 DEGs after transfection with c.515G > A and c.522C > T expression vectors. (D) Gene expression levels of RHOXF2/2B DEGs after transfection with c.202G > A, c.411C > T, c.679G > A, and c.381dupG expression vectors. Transformed data are represented as whiskers with 5–95 percentiles. *Results are significant after Bonferroni correction for multiple testing (P < 0.01).