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. Author manuscript; available in PMC: 2019 Jun 28.
Published in final edited form as: J Med Chem. 2017 Dec 28;61(12):5108–5121. doi: 10.1021/acs.jmedchem.7b01457

Figure 2.

Figure 2.

X-ray structures of mouse P-gp solved in various inward-facing conformations. Shown below the structure cartoons are the PDB codes together with the distances measured between the N607 and T1262 Cα positions (marked by red dots) in the separated NBDs. The N- and C-terminal TMD-NBD halves are depicted in blue and green, respectively. A short flexible linker, unresolved in these X-ray structures, is depicted by black dashes in the first structure that connect the end of NBD1 and the start of TMD2. Shown on far right is a structure (5KOY) with ATP (rendered in spheres) bound in NBD1. Estimated lipid bilayer positions are indicated in grey lines.