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Chemical modifications of several microtubule-targeting anticancer drugs to reduce P-gp-medicated efflux. The positions of chemical modifications on Epothilone B (A), paclitaxel (B), and vinblastine (C) are indicated in small shadowed boxes. Decreased susceptibility to P-gp efflux after modifications in (B) and (C) is indicated by the lower IC50 values against various drug-resistant, P-gp overexpressing cell lines.
