Skip to main content
. 2018 Nov 16;9(90):36083–36101. doi: 10.18632/oncotarget.26300

Figure 2. Cellular proliferation and survival effects of exosomes.

Figure 2

In panels A-F, U87 glioma cells are represented with a “U”, STS26T MPNST cells with an “S”, and SH-SY5Y neuroblastoma cells with a “B”. The number following the cell line letter is the dosage of radiation used; either 3R or 12R. The cells were either exposed to exosomes from not irradiated cells “NR” or to exosomes (Exos) from cells that received one of the two doses of radiation (“3R” or “12R”). The effect of the exosomes on cellular proliferation is shown in Panels A-F: (A,B) U87 glioma cells, (C,D) STS26T MPNST cells, (E,F) SH-SY5Y neuroblastoma cells. Increased recipient cancer cell survival after radiation due to the effect of exosomes in Panels G-L: (G,H) U87 glioma cells, (I,J) STS26T MPNST cells, (K,L) SH-SY5Y neuroblastoma cells) (*p<.05, **p<.01). In Panels M and N are data showing there was no increase in reactive oxygen species of cells incubated with exosomes compared to control for either (M) 3Gy or (N) 12Gy radiated (represented with an “R”) or non-radiated (“NR”). The results show increased proliferation and increased survival to radiation when cells are exposed to exosomes from irradiated cells.