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. 2018 Nov 16;9(90):36083–36101. doi: 10.18632/oncotarget.26300

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Copyright: © 2018 Mrowczynski et al.

This article is distributed under the terms of the Creative Commons Attribution License (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.

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Representative IVIS images of (A) Control (B) Non-radiation exosomes (C) Radiation-derived exosomes, (D) Radiation-derived exosomes plus daily heparin (Hep), (E) Radiation-derived exosomes plus daily simvastatin (SMV) treatment. Mice treated with radiation-derived exosomes had visually larger tumors when compared to control. When co-treating mice with radiation-derived exosomes plus heparin or simvastatin, the tumor size decreased and was comparable to control levels. (F) Tumor progression over time was quantified with IVIS counts. Mice treated with radiation-derived exosomes (represented as “Rad Exos”) had an increase in tumor progression and when co-treating with Hep or SMV tumor progression was similar to baseline (p<0.05). (G) Mice treated with radiation-derived exosomes had a decrease in survival time but when co-treating with heparin or simvastatin the mouse survival increased.