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. 2018 Dec 5;4(12):eaau9812. doi: 10.1126/sciadv.aau9812

Fig. 4. Vertical transmission of RVFV in two dams resulted in stillborn pups with physical abnormalities and high viral titers.

Fig. 4

(A to D) Dam 1 was inoculated with 175 PFU and died giving birth at 8 dpi. Dam 1 delivered 13 stillborn pups, with 2 remaining in the uterus. (A) Pictures of individual pups are shown as numbered. Uterus with pups 13 and 14 within birth canal after demise. (B) vRNA within maternal tissue. (C) vRNA and (D) infectious virus within peritoneal cavity of indicated pups. The three pups not included in the graphs were used for other analyses. (E to H) Dam 2 was inoculated with 175 PFU and survived with no clinical signs of disease. Dam 2 delivered seven pups to full-term; five were dead and two were alive but subsequently consumed by the dam (data not available). (E) Pictures of individual pups as labeled. A normal pup from an uninfected dam is shown for comparison. (F) vRNA within maternal tissue. (G) vRNA and (H) infectious virus within peritoneal cavity of indicated pups. For all graphs, red square data points indicate either dam or pup demise. Blue circle data points indicate dam or pup survival.