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. 2018 Dec 5;5:34. doi: 10.1186/s40658-018-0233-8

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — The datasets used for this study: a simulation from XCAT2 phantom consisting of the bladder, three lesions (L1–L3) and one background lesion (B) placed at different distances (shown in brackets) from the bladder; b NEMA phantom consisting of a hot bottle at the centre, surrounded by six spheres (S1–S6) with diameters shown in brackets. The blue spheres (B1–B6) were used to estimate the background activity for the estimation of contrast-to-noise ratio (CNR); c patient data showing high activity in the spleen and liver