Fig. 11.

A–E: The change in the starting point of the stable limit cycle and the Hopf bifurcation point as parameters $g_L$, $g_K$, $g_{\mathit{Na}}$, $g_s$, and $g_M$ change. The vertical distance between the blue and red curves is the size of the bistability window. F: The size of the bistability window as parameters $g_L$, $g_K$, $g_{\mathit{Na}}$, $g_s$, and $g_M$ change. The baseline at around 0.86 μA/cm² is the size of the bistability window with default parameter values. Changes in $g_K$, $g_s$, and $g_M$ increase the bistability window size significantly. Increasing the maximal M-current conductance $g_M$ to approximately 3.2066 mS/cm² has the most dramatic effect