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. 2018 Dec 5;9(12):1169. doi: 10.1038/s41419-018-1224-3

Fig. 6. FGF14 serves as the downstream target of ZNF750.

Fig. 6

a ZNF750 binding site with and without mutation in the promoter of FGF14. b Luciferase activity of FGF14 wild-type or mutated NPC cells with or without ZNF750 overexpression. c, d CCK-8 assay of NPC cells with ZNF750 overexpression or FGF14 knockdown. e, f Colony formation assay of NPC cells with ZNF750 overexpression or FGF14 knockdown. g, h Tumor cell absorbance intensity and the quantification analysis of vector (n = 5), ZNF750 overexpression (n = 5), and ZNF750 overexpression combined with FGF14 knockdown groups two weeks after tumor cell implantation in mice. i, j Quantitative RT-PCR detection of ZNF750 and FGF14 expression in xenograft tumor cells. *p < 0.05, **p < 0.01, ***p < 0.001