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. 2018 Dec 5;8:17661. doi: 10.1038/s41598-018-35971-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Result of sensitivity analysis of the effects of undiagnosed positive examinees at primary examination on p-values of the spatial analysis. Box-plots were drawn by 100 Monte Carlo simulation runs for p-value of the most likely cluster computed by flexibly shaped spatial scan statistics, the adjusted p-value of maximised excess events test (MEET), and Wald tests of univariate Poisson regression about the coefficient of the explanatory variable. The white circles represent the p-values obtained from the analysis not considering the effects of undiagnosed positive examinees (the same numbers reported in Figs 2 and 3 and Table 1).