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. 2018 Dec 5;9(12):1167. doi: 10.1038/s41419-018-1220-7

Fig. 8. A working model for DANCR-mediated TNBC tumorigenesis.

Fig. 8

DANCR interacts with RXRA, and highly promotes GSK3β phosphorylating RXRA, and inhibits RXRA binding with PIK3CA promoter to upregulate its transcription, resulting in activating PI3K/AKT signaling pathway and TNBC tumorigenesis