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. 2018 Dec 5;7:103. doi: 10.1038/s41377-018-0093-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Normal retinal vessels in albino rabbit; b RNV induced by VEGF in albino rabbit; c composite pseudo color image of albino rabbit showing the retinal vessels in the same area before and after VEGF injection; d normal retinal vessels in pigmented rabbit; e RNV induced by VEGF injection in a pigmented rabbit; f composite pseudo color image of pigmented rabbit showing the retinal vessels in the same area before and after VEGF injection; g quantification of retinal vessels and RNV in albino and pigmented rabbits before and after VEGF injection using fill factor—statistical significance of the fill factor between a normal blood vessel and RNV (albino: n = 5; pigmented: n = 3; P < 0.05); h quantification of retinal vessels and RNV in albino rabbits before and after VEGF injection using the vessel size—statistical significance of the vessel size between a normal blood vessel and RNV (P < 0.05); i quantification of retinal vessels and RNV in pigmented rabbits before and after VEGF injection using the vessel size—statistical significance of the vessel size between a normal blood vessel and RNV (P < 0.05). (Pseudo color indicates the normal retinal vessels; grayscale shows the retinal vessels after injection with VEGF)