Fig. 3.

Deacetylases can be classified in three major groups, according to their catalytic sites. Exemplary active site arrangements and simple catalytic mechanisms of a de-N-acetylases (PDB code 4F9D²⁵), b de-O-acetylases (PDB code 3M81⁵⁴), and c class III HDACs (PDB code 4I5I⁶⁵). N-acetyl is highlighted in blue and O-acetyl in red, respectively. Typical catalytic site residues are shown with white carbon atoms and metal binding residues in a are shown with carbon atoms colored in gray