Fig. 4.

Deacetylases feature a signature binding groove with electronegative charge. a–f Protein surface representations of deacetylases with different substrate specificities. Electrostatic surface potentials are contoured from −12.8 kT e⁻¹ (red) to +12.8 kT e⁻¹ (blue). g–k Divalent metal coordination by different deacetylases. Distances are in Å. l Dimeric composition and m metal binding sites (white) and substrate binding residues (green) of the N-acetylglucosamine-6-phosphate deacetylase from Bacillus subtilis