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. 2018 Dec 5;9(12):1165. doi: 10.1038/s41419-018-1149-x

Fig. 4. NR2C2-uORF-mediated NR2C2 expression by down regulating its mRNA.

Fig. 4

a Immunohistochemistry of NR2C2-uORF peptide in nontumorous brain, low-grade glioma, and high-grade glioma tissues. Original magnification: ×100. Scale bar = 50 μm. b The expression of uORF in normal brain tissues (NBTs), low grade (grade I–II) glioma tissues (LGGs), and high grade (grade III– IV) glioma tissues (HGGs). Error bars represent as the mean ± SD (n = 3, each group). *P < 0.05, **P < 0.01. c Western blot analysis for uORF and NR2C2 in U87 and U251 cells, after uORF was overexpressed in cell lines. Error bars represent as the mean ± SD (n = 3, each group). **P < 0.01. d Relative expression of NR2C2 mRNA variant 1 in U87 and U251 cells with the overexpression of uORF. Error bars represent as the mean ± SD (n = 3, each group). ***P < 0.001