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. 2018 Dec 5;50(12):158. doi: 10.1038/s12276-018-0186-y

Fig. 1. Streptozotocin (STZ)-induced T1DM mice showed a greater extent of osteopenia in cancellous bone than in cortical bone.

Fig. 1

a Representative X-ray images of mouse femur. b, c Trabecular and cortical parameters, including bone volume per total volume (BV/TV), trabecular thickness (Tb.Th.), trabecular number (Tb.N.), trabecular separation (Tb.Sp.), cortical bone area per tissue area (BA/TA), and cortical thickness (CT.Th.), as measured by micro-CT. n = 9/control, 7/T1DM. d Static and dynamic histomorphometric analyses were performed in the trabecular bone and endocortical surface of the femur. N.Ob/T.Ar osteoblast number per tissue area, Ob.S/BS osteoblast surface per bone surface, BFR/BS bone formation rate per bone surface. n = 9. e mRNA expression levels of osteoblast markers in trabecular and cortical bone. ALP alkaline phosphatase, OSX osterix. n = 8. f Histomorphometric quantification of TRAP-stained osteoclasts in the trabecular bone and endocortical surface of the femur. n = 9. N.Oc/T.Ar osteoclast number normalized to tissue area, Oc.S/BS osteoclast surface normalized to bone surface. Data are expressed as the mean ± SD. *P < 0.05, **P < 0.01 versus Control group by an unpaired t-test. NS not significant, P > 0.05