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. 2018 Dec 5;9:5178. doi: 10.1038/s41467-018-07514-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — Schematic representation of the proposed model. a In the absence of uPARAP, VEGFR-2/VEGFR-3 heterodimerisation is promoted leading to Crk phosphorylation by VEGFR-2, which impairs its interaction with its partners (JNK and paxillin). Hyperbranched lymphatic vasculature is observed in the absence of uPARAP in vivo. b uPARAP acts as a gatekeeper, restricting VEGFR-2/VEGFR-3 heterodimerisation and the subsequent phosphorylation of Crk, which acts as a bridge between partners enhancing JNK signaling