Table 3.
Top 20 IPA Canonical Pathways Based on the Most Central Genes.
| Ingenuity Canonical Pathways | −log10(p-value) | Genes | Ratio |
|---|---|---|---|
| HMGB1 Signalling | 14.2 | FOS, PIK3CA, JUN, CCL2, MAPK1, MAPK8, IL1B, PLAT | 0.06 |
| Glucocorticoid Receptor Signalling | 13.6 | FOS, PIK3CA, JUN, CCL2, MAPK1, CREB1, MAPK8, IL1B, ESR1 | 0.03 |
| GDNF Family Ligand-Receptor Interactions | 11.3 | FOS, PIK3CA, JUN, MAPK1, CREB1, MAPK8 | 0.08 |
| Neurotrophin/TRK Signalling | 11.3 | FOS, PIK3CA, JUN, MAPK1, CREB1, MAPK8 | 0.08 |
| Estrogen-Dependent Breast Cancer Signalling | 11.2 | FOS, PIK3CA, JUN, MAPK1, CREB1, ESR1 | 0.08 |
| LPS-stimulated MAPK Signalling | 11 | FOS, PIK3CA, JUN, MAPK1, CREB1, MAPK8 | 0.07 |
| HGF Signalling | 10.2 | FOS, PIK3CA, JUN, MAPK1, HGF, MAPK8 | 0.05 |
| Renin-Angiotensin Signalling | 10.1 | FOS, PIK3CA, JUN, CCL2, MAPK1, MAPK8 | 0.05 |
| IL-6 Signalling | 9.92 | FOS, PIK3CA, JUN, MAPK1, MAPK8, IL1B | 0.05 |
| Aryl Hydrocarbon Receptor Signalling | 9.66 | FOS, JUN, MAPK1, MAPK8, IL1B, ESR1 | 0.04 |
| Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis | 9.38 | FOS, PIK3CA, JUN, CCL2, MAPK1, CREB1, IL1B | 0.02 |
| IL-2 Signalling | 9.37 | FOS, PIK3CA, JUN, MAPK1, MAPK8 | 0.08 |
| UVB-Induced MAPK Signalling | 9.3 | FOS, PIK3CA, JUN, MAPK1, MAPK8 | 0.08 |
| IL-10 Signalling | 9.23 | FOS, JUN, MAPK1, MAPK8, IL1B | 0.07 |
| EGF Signalling | 9.23 | FOS, PIK3CA, JUN, MAPK1, MAPK8 | 0.07 |
| Acute Phase Response Signalling | 9.17 | FOS, PIK3CA, JUN, MAPK1, MAPK8, IL1B | 0.04 |
| Chemokine Signalling | 9.14 | FOS, JUN, CCL2, MAPK1, MAPK8 | 0.07 |
| Toll-like Receptor Signalling | 9.05 | FOS, JUN, MAPK1, MAPK8, IL1B | 0.07 |
| CD40 Signalling | 8.93 | FOS, PIK3CA, JUN, MAPK1, MAPK8 | 0.06 |
| Dendritic Cell Maturation | 8.86 | PIK3CA, LEP, MAPK1, CREB1, MAPK8, IL1B | 0.03 |
The 14 genes identified by CentiScaPe to be the most central genes within the merged network based on the four centrality measures were used as input for IPA to analyse pathway enrichment. This table represents the enriched pathways based on these genes with −log10(p-value) as a significance measure and the ratio as the proportion of significant DEGs measured over the total genes within the pathway. HMGB1 signalling, Glucocorticoid receptor signalling, as well as the various interleukin pathways indicate disrupted inflammation as a central influence within the cross-species shared network. The ratio represents the proportion of the 14 central genes to all the genes involved in the canonical pathway.