Table 1.
Optimization of quercetin (QUE)-loaded lecithin-stabilized polymeric micelles (LsbPMs).
| Quercetin (mg) | TPGS (mg) | Lecithin (mg) | size (nm) (PI) mean ± SD | EE (%) | DL (%) | Stability |
|---|---|---|---|---|---|---|
| 20 | >3000 | PPT | ||||
| 30 | 40 | >3000 | PPT | |||
| 60 | >3000 | PPT | ||||
| 80 | >3000 | PPT | ||||
| 20 | >3000 | PPT | ||||
| 40 | 40 | >3000 | <15 min | |||
| 60 | >3000 | <15 min | ||||
| 80 | 92.2 ± 0.35 (0.468 ± 0.016) |
98.88 | 4.72 | <5 days | ||
| 50 | 50 | >3000 | <1 h | |||
| 60 | 97.6 ± 3.07 (0.653 ± 0.078) |
95.25 | 5.03 | <3 days | ||
| 70 | 84.3 ± 2.12 (0.453 ± 0.321) |
93.36 | 4.84 | <3 days | ||
| 6 | 60 | 50 | 97.6 ± 3.07 (0.653 ± 0.078) |
93.37 | 5.34 | <3 days |
| 60 | 83.3 ± 5.07 (0.638 ± 0.023) |
93.23 | 4.89 | <3 days | ||
| 70 | 30 | 83.4 ± 0.63 (0.837 ± 0.031) |
86.81 | 4.82 | <2 days | |
| 40 | 83.1 ± 2.26 (0.503 ± 0.056) |
91.47 | 5.24 | <3 days | ||
| 50 | 74.3 ± 0.26 (0.534 ± 0.039) |
94.26 | 4.38 | <3 days | ||
| 80 | 30 | 83.2 ± 0.54 (0.637 ± 0.038) |
87.55 | 4.02 | <1 day | |
| 40 | 73.4 ± 0.34v (0.643 ± 0.023) |
92.56 | 4.81 | <2 days | ||
| 90 | 20 | >3000 | <1 h | |||
| 30 | 85.5 ± 2.33 (0.510 ± 0.090) |
95.68 | 5.01 | <3 days |
Abbreviations: PI, polydispersity index; PPT, precipitation; EE, encapsulation efficiency; DL, drug loading.