Table 3.
Pharmacokinetic parameters of quercetin (QUE) after intravenous and oral administration of QUE-loaded lecithin-stabilized polymeric micelles (LsbPMs) and free QUE to SD rats.
| Free QUE (IV) | QUE-loaded LsbPMs (IV) | Free QUE (Oral) | QUE-loaded LsbPMs (Oral) | |
|---|---|---|---|---|
| Dose (mg/kg) | 50 | 50 | 100 | 100 |
| Tmax (h) | N/A | N/A | 0.25 | 0.25 |
| T1/2 (h) | 7.31 ± 6.73 | 10.84 ± 5.24 | N/A | N/A |
| Cmax (µg/ml) | 49.65 ± 15.76 | 87.99 ± 28.64 | 0.53 ± 0.22 | 1.52 ± 1.31 |
| AUC0-inf (h·µg/ml) | 17.51 ± 6.15 | 27.74 ± 8.82 | 0.25 ± 0.12 | 0.90 ± 0.26 |
| V (l/kg) | 24.32 ± 15.28 | 26.23 ± 14.8 | N/A | 19.76 ± 14.05 |
| CL (l/min/kg) | 3.12 ± 1.44 | 1.78 ± 0.44 | N/A | 102.29 ± 42.80 |
| BA (%) (IV-IV) | 100 | 158 | ||
| BA (%) (IV-Oral) | 1.42 | 5.13 | ||
| BA (%) (Oral-Oral) | 100 | 360 |
Data are presented as the mean ± SD deviation (n = 5).
Abbreviations: Tmax, the time to reach Cmax; T1/2, half-life of the drug; Cmax, maximum plasma drug concentration; AUC0–inf, area under the receiver operating curve at 0 to infinity; V, volume of distribution; CL, clearance; BA, bioavailability.