Fig. 2. KIT ^Wsh mice fail in timely recovery from colitis due to MC deficiency.

a Alterations in body weight as the percentage of initial weight at the start of experiments during a 15-day observation (24 WT mice and 14 KIT ^Wsh mice). b Survival rate for WT and KIT ^Wsh mice after DSS insult. c Whole colon lengths from sham, activation phase, and remission phase. d Disease score evaluated as weight loss, feces, rectal bleeding, and general appearance as indicated. e Representative H&E staining images of transverse colon. f Pathological scores from colonic sections, calculated as indicated. g Serum FITC-dextran quantified as a measure of intestinal permeability. h Percentage of positive cells for Ki-67 immunostaining. i Representative stain of Ki-67. j Heat map of relative transcriptional level of selected mRNA involved in mucosal recovery and homeostasis maintenance. Data are mean ± SD. Student t-test, *P < 0.05; **P < 0.01