Fig. 6. MC-dependent IL-33/ST2 signaling pathway is required for recovery from colitis.

a Percentage difference in mass from day 0 for WT + IgG, WT + anti-ST2 Ab, Kit ^Wsh  +  IgG and Kit ^Wsh  +  ST2 Ab groups (6 mice/group). b Serum FITC-dextran quantified as a measure of intestinal permeability. c Measurement and comparison of colon length in remission phase. d Representative H&E plus alcian blue staining images of transverse colon (original magnification ×400). e Pathological grading of colitis. f Disease score from a comprehensive evaluation as indicated. Relative mRNA for g ZO-1, h ANGPTL2, i Reg3β, and j Reg3γ from real-time-quantification PCR. Data were pooled from three repeated experiments. Data are mean ± SD. Student t-test, *P < 0.05; **P < 0.01