Fig. 7. Pathological analysis of brain and the skeletal muscle of EV-A71-infected mouse models.

Sporadic neuronal necrosis and neuronophagia (arrowhead) in the brain (1) and Inflammatory cell infiltration (arrowhead) in the skeletal muscle (5) of mouse model with CDV-Isehara/I.C.; glial nodule (arrow) and neuronophagia (arrowhead) in the brain (2) and severe necrotizing myositis with a mass of inflammatory cell infiltration (arrow) in the skeletal muscle (6) of mouse model with CDV-Isehara/I.V.; perivascular cuffing (arrowhead), partial neuronal necrosis and neuronophagia in the brain (3) and degeneration and necrosis in muscle bundles with inflammatory cell infiltration (arrowhead) (7) in mouse model with CMU4232/I.V.; the brain (4) and the skeletal muscle (8) of MOCK mouse with DMEM/I.V. (magnification: 200 × ). Representative samples are shown for each group