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. 2018 Nov 29;9:567. doi: 10.3389/fgene.2018.00567

FIGURE 3.

FIGURE 3

Effects of ethanol on Gabra2 gene expression in stress- and reward-related brains regions of βE +/+ and βE –/– male mice. Gabra2 mRNA expression following binge-like consumption of either EtOH and water or water only in the DID paradigm. Two-way ANOVAs were used to examine the main and interaction effects of genotype (βE +/+, βE –/–) and treatment (EtOH drinker, water drinkers) in each brain region, results of which are depicted within each graph. (A) In the BNST, there was a significant interaction, but post hoc analysis did not reveal any significant differences between groups. (B) In the CeA, post hoc analysis indicated that binge-like EtOH consumption increased Gabra2 expression in βE –/– males. (C) In the NAc, there was a significant interaction, but post hoc analysis revealed no significant differences between groups. (D) Similar to the NAc, in the VTA there was a significant interaction, but post hoc analysis revealed no significant differences between groups. ∗p < 0.05 compared with the water group within the same genotype. Data are presented as means ± SEM; Bonferroni correction for multiple comparisons.