Table 2.

Incidence and HRs of gallbladder stone disease (GSD in type 1 diabetes cohort or type 2 diabetes cohort compared with the corresponding control cohort.

	Type 1 diabetes		Type 2 diabetes
	No	Yes	No	Yes
	(N = 28,060)	(N = 7,015)	(N = 51,689)	(N = 51,689)
Person-years	181,341	45,985	453,383	435,806
Follow-up time (y) Median ± (SD)	6.46 ± 3.95	6.56 ± 3.95	6.33 ± 3.40	6.58 ± 3.92
GSD
Event	134	17	1611	2249
Rate#	7.39	3.70	35.5	51.6
Crude HR (95% CI)	1 (Reference)	0.50 (0.30, 0.83)**	1 (Reference)	1.45 (1.36, 1.54)***
Adjusted HR (95% CI)	1 (Reference)	0.48 (0.25, 0.92)*	1 (Reference)	1.55 (1.41, 1.69)***

Rate#, incidence rate, per 10,000 person-years; Crude HR, relative hazard ratio; SD, standard deviation; 95% CI, 95% confidence interval; CAD, coronary artery disease; Adjusted HR, multivariate analysis including age, sex, hypertension, hyperlipidemia, cirrhosis, stroke, CAD, chronic kidney diseases, alcohol-related illness, obesity, and number of parity.

^*P < 0.05,

^**P < 0.01,

^***P < 0.001.