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. 2018 Nov 29;9:709. doi: 10.3389/fendo.2018.00709

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Copyright © 2018 Zhou, Wang, Wen, Zheng, Ye, Liu, Wu, Zou, Liu, Wang, Dong, Huang, Du, Zhu, Chen, Huang, Zeng, Han, Zhang, Nie, Yang and Jing.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The association between promoter methylation in NLRP3, AIM2, and ASC genes and T2DM complication (T2DM without any complication vs. T2DM with microvascular complications; T2DM without any complication vs. T2DM with macrovascular complications; T2DM without any complication vs. T2DM with both microvascular and macrovascular complications). (A) NLRP3 total methylation level; (B) NLRP3 each CpG methylation level; (C) AIM2 total methylation level; (D) AIM2 each CpG methylation level; (E) ASC total methylation level; (F) ASC each CpG methylation level. The Kruskal-Wallis test was used among T2DM subgroups and a Dunn-Bonferroni test for post-hoc comparisons, * Bonferroni-corrected P < 0.05, ** Bonferroni-corrected P < 0.001.