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Schematic diagram of the experimental procedures. (A) Neonatal male mice (B6 or BTBR) were injected with metformin (MET; 200 mg/kg) or saline (SAL) from P7 to P14 once per day. (B) The behavior tests were conducted at the age of 8 weeks. (C) The effects of MET on the average body weight of mouse pups. OFT, Open Field Test; EPM, Elevated Plus-Maze. *p < 0.05, **p < 0.01.
