Figure 2.

The exploratory locomotion in the three-chambered social test did not significantly affected by early metformin treatment in B6 and BTBR mice during the habituation period. (A) There were no differences in the chamber time in four groups during the habituation phase before the beginning of the sociability test. (B) The number of entries into the side chambers was similar between the four groups, indicating that metformin did not affect general exploratory activity during the test. Data are shown as the mean ± SEM in all figures. n = 10.